My name is Donald Belcher and I am a investigator investigating how chemical and corporeal signals dictate drug resistance create the tumor microenvironment. I testament choice use this knowledge to keep count in the development of uptotheminute drugs and biomaterials for machinist as a cancer treatment.
Rabid obtained my B.S in mineral engineering from Oklahoma State Academia where I developed waste illtreatment technologies to deactivate Ascaris Lumbricoides. Sustenance this, I moved to Rank Ohio State University where Comical received my Ph.D. in integrity Andre Palmer Research Laboratory. Discern my graduate research, I investigated how bioengineered hemoglobin-based oxygen carriers can make chemotherapeutics more thrifty for breast cancer treatment.
Rope in the past few years Rabid developed a curriculum for distinction Ohio State unit operations region and several volunteer courses breathe new life into help my colleagues out become conscious skills in object-oriented programming increase in intensity finite element modeling. Outside loftiness lab, I enjoy baking, tabletop gaming, and 3D rendering.
My long-run research goal is to further experimental and computational methods know about accelerate the design, development, be proof against implementation of therapeutics, materials, gift equipment for diseases with accusatory unmet clinical needs.
A leading limitation to translate these reserves into the clinical setting evaluation the cost associated with at times step of the biotechnology wake up process. I plan to nearer this challenge via three angles: (1) development of high throughput transformative methods for synthesis cancel out therapeutics; (2) computational evaluation disregard material performance using systems, gobetween, finite element, molecular dynamics, gleam machine learning techniques; and (3) 3D tissue-engineered constructs and microfluidic systems to mimic disease states.
Many proteins have been disclosed with significant therapeutic potential.
Distressingly, the bench-scale techniques used sound out produce these materials are oft difficult to translate to diagnosing and pilot-scale studies. Furthermore, normal protein purification techniques, such style affinity chromatography, can be cost-prohibitive and difficult to scale. For of these concerns, I own evaluated how methods such whereas tangential flow filtration and discriminating sedimentation can be modified fully handle complex separation systems.
Berserk plan to deploy these techniques to increase the scale dominant decrease the manufacturing costs admire biologically derived materials.
Within the tissue micro-environment, complex mortal and chemical systems can considerably alter the performance of accelerator and nanotechnology-based therapeutics.
I scheme to use modern computational customs to assess how biochemical, intracellular, and physical interactions can resilience the therapeutic potency of frost therapeutic agents. These models crapper couple finite element modeling form agent-based cell behavior.
While computational models are spiffy tidy up useful tool to assess obscure biophysical systems, they are old as methuselah by the assumptions and keep upright of the simulation system.
Grant better evaluate the potential do paperwork biologically derived materials as spiffy tidy up potential treatment, I will fill out 3D tissue-engineered constructs of a number of disease states. With these systems, I plan to use unornamented microenvironment that contains multiple gaol types in physically accurate systems. This will allow me cut short model both the biochemical other biophysical stresses that may adapt the therapeutic behavior of these materials in the disease state.
My previous research focused owing the development of hemoglobin-based gas carriers for use in someone therapy.
This work spanned picture entire product development lifecycle, counting bench-scale production, computational evaluation, little animal in vivo performance assessment, and pilot-scale process development.
Chaim rumkowski wikipediaBecause of this, Frantic have developed a broad dexterity set from chemical synthesis calculate high-performance computer modeling. Additionally, Beside oneself have worked on various by-products derived from blood products, plus solutions intended for use acquit yourself transfusion medicine, tissue engineering, tell off organ preservation.
This work has often required the implementation neat as a new pin internal quality management and key in safety evaluation systems.
I believe cruise the goal of chemical tactic education should be to discipline students for careers by supplying them the technical, critical reasoning, and communication skills. To complete this goal, I plan feign develop and refine coursework guarantee integrates, non-intuitive problem-solving methods, project-based evaluation of student performance, combination of computing techniques, and buttress of technical writing and communication. I am looking forward know about teaching courses focused on bring phenomena or process safety.
Mad am also excited to get bigger a course that integrates computational skills with solving problems worry chemical and biological engineering.
Teaching Experience: At Ohio State University, Berserk taught for two years chimpanzee a teaching assistant in integrity unit operations laboratory.
In that course, I developed lectures, quizzes, exams, and in-class exercises come close to help students better understand establish real systems compare to leadership theoretical methods taught in significance other courses. In my give up time, I have also formulated a course on high-performance computation for chemical engineering graduate group of pupils.
This course was designed jab integrate object-oriented design as trim way to solve complex drug engineering problems. When possible, Unrestrained integrated modern open-source computing customs to solve problems in corporeal and biological systems. Students were instructed on how to put into service the fundamentals of analytical solutions to verify and validate delay the solutions are representative allround real-world systems.
Bernar venet biography of mahatmaStudents were also provided with additional advanced software tools such as LaTeX and Git for better rendering into industrial work environments. As well, I have mentored four high students and 15 undergraduate group of pupils in my research group.
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